TULSA, Oklahoma - The highly anticipated Presidential debate took place at the University of Denver, Wednesday night.

This is the first of three debates over the next three weeks. Tonight's topic : domestic policy which includes the biggest thing weighing on voters' minds right now, the economy.

But, there's another hot topic on tonight's agenda: Healthcare.

President Barack Obama and Mitt Romney have both spent a lot of time planning what they'll say, knowing a simple slip could cost them the White House.

Romney has been trailing in the polls. He's hoping to gain traction in key states Wednesday night. With five weeks until election day, President Obama knows a lot can happen in that time.

Both parties have set up websites to respond, in real time, to their opponents' claims during these debates.