Keylan Boone scored 12 points off the bench and Moussa Cisse scored 10 and Oklahoma State bounced back beating Prairie View A&M 72-59 on Sunday.
The visiting Oakland Grizzlies left Gallagher-Iba Arena with a 56-55 upset victory over the Cowboys on Friday.
Kalib Boone made a layup and 1 of 2 free throws and Keylan Boone made a 3-pointer and two foul shoots in successive possessions and Oklahoma State (2-1) led 24-8 with 5:54 before halftime.
The Cowboys led 38-15 at halftime before the Panthers went on a 15-0 run to start the second half as four different players scored to cut the deficit to eight.
Later, Rondell Walker made a 3 for a 45-33 Cowboys lead with 12:38 left and Oklahoma State led by double figures for the remainder. Twelve players scored for Oklahoma State.
Drell Roberts scored 27 points for the Panthers (0-4) and Dewayne Cox 11.