A collision closed the eastbound lanes of Highway 51 at 137th West Avenue Friday night.
The lanes are going to remain closed for a couple hours, the Oklahoma Highway Patrol reported.
The crash involved a car versus a motorcycle.
One person was in the car and two people were on the motorcycle.
The person in the car was uninjured.
A woman riding on the motorcycle was taken to a local hospital by helicopter.
A man on the motorcycle was transported by ambulance.
Neither of the motorcyclists were wearing helmets, the OHP reported.
The westbound lanes of the highway were unaffected.