Bobby Abreu hit his third homer in two games as the Philadelphia Phillies beat the Colorado Rockies, 3-2, despite three hits from Helton.
Helton went 3-for-4 to raise his average three points. He singled in the first inning, flied out in the third, and doubled in the fifth and eighth innings.
But with Colorado trailing by a run in the seventh, Helton took a called strike on Robert Person's 3-1 pitch as Mike Lieberthal threw out Juan Pierre at second to end the inning.
"I was looking for a fastball in so I could drive the ball, but it was a fastball away," Helton said.
Abreu, batting .389 (14-for-36) since moving to the leadoff spot nine games ago, gave the Phillies a 2-0 lead in the third with his 21st homer.